Abrogation of esophageal carcinoma development in miR-31 knockout rats
نویسندگان
چکیده
منابع مشابه
Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent
microRNA regulation network is important for the cancer genetic heterogeneity. Relative to the increasing numbers of microRNA's targets identified, upstream regulatory mechanisms that control functional microRNAs are less well-documented. Here, we investigated the function of miR-31, a pleiotropically-acting microRNA, in esophageal squamous cell cancer (ESCC). We demonstrated that miR-31 only e...
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15 صفحه اولDysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate gene expression and are aberrantly expressed in cancers. Here we investigated whether chronic ZD (23 weeks) also induces a protumorigenic microRNA signature. Using the nanoString technology, we eva...
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SUMMARY 13 Consecutive patients who underwent endoscopic Nd - Y AG laser therapy for palliation of advanced esophageal cardnoma were treated between Oct 1989, and July 1991 , in Khatam - al -Anbia Hospital. All patients had severe dysphagia and conventional methods such as surgery , Radiotherapy and chemotherapy failed to treat them. Undoubtedly without laser therapy these patients did not see...
متن کاملDysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma.
OBJECTIVES To identify differentially expressed miRNA between oral squamous cell carcinoma (OSCC) and non-cancer (NC) and to associate these with clinico-pathological parameters. MATERIALS AND METHODS miRNA microarray profiling was utilized to obtain the expression profile of miRNAs in four OSCC and four NC samples. The expression of miR-31 and miR-375 was further validated in 26 OSCC and thr...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1920333117